These Were the 2 Worst-Performing Stocks in the Nasdaq-100 in May 2025
Think every Nasdaq-100 stock was a winner last month? The numbers might surprise you.

The Nasdaq-100 market index holds a lot of volatile stocks. Some of its top performers seem overvalued today, while others seem to have room for further growth. The index as a whole rose 9.1% last month, outpacing the S&P 500 (SNPINDEX: ^GSPC) return of 6.3%.
But what about the other end of the spectrum? Let's take a quick look at the two worst performers on the Nasdaq-100 in May 2025.
Biotech giant Regeneron (NASDAQ: REGN) was on track for a quiet May, holding almost exactly steady with just a couple of days left in the month. A disappointing earnings report changed that story in a hurry, driving Regeneron's stock 18% lower on the last trading day in May.